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Internal dosimetry study of [82Rb]Cl using a long axial field-of-view PET/CT.
Mercolli, Lorenzo; Bregenzer, Carola; Diemling, Markus; Mingels, Clemens; Rominger, Axel; Sari, Hasan; Seibel, Sigrid; Sohlberg, Antti; Viscione, Marco; Caobelli, Federico.
Afiliação
  • Mercolli L; Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. lorenzo.mercolli@insel.ch.
  • Bregenzer C; Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Diemling M; Hermes Medical Solutions, Stockholm, Sweden.
  • Mingels C; Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Rominger A; Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Sari H; Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland.
  • Seibel S; Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Sohlberg A; Hermes Medical Solutions, Stockholm, Sweden.
  • Viscione M; Department of Clinical Physiology and Nuclear Medicine, Päijät-Häme Central Hospital, Lahti, Finland.
  • Caobelli F; Department of Nuclear Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Eur J Nucl Med Mol Imaging ; 51(7): 1869-1875, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38407598
ABSTRACT

PURPOSE:

Long axial field-of-view (LAFOV) positron emission tomography (PET) systems allow to image all major organs with one bed position, which is particularly useful for acquiring whole-body dynamic data using short-lived radioisotopes like 82Rb.

METHODS:

We determined the absorbed dose in target organs of three subjects (29, 40, and 57 years old) using two different methods, i.e., MIRD and voxel dosimetry. The subjects were injected with 407.0 to 419.61 MBq of [82Rb]Cl and were scanned dynamically for 7 min with a LAFOV PET/CT scanner.

RESULTS:

Using the MIRD formalism and voxel dosimetry, the absorbed dose ranged from 1.84 to 2.78 µGy/MBq (1.57 to 3.92 µGy/MBq for voxel dosimetry) for the heart wall, 2.76 to 5.73 µGy/MBq (3.22 to 5.37 µGy/MBq for voxel dosimetry) for the kidneys, and 0.94 to 1.88 µGy/MBq (0.98 to 1.92 µGy/MBq for voxel dosimetry) for the lungs. The total body effective dose lied between 0.50 and 0.76 µSv/MBq.

CONCLUSION:

Our study suggests that the radiation dose associated with [82Rb]Cl PET/CT can be assessed by means of dynamic LAFOV PET and that it is lower compared to literature values.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Radiometria / Radioisótopos de Rubídio / Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Radiometria / Radioisótopos de Rubídio / Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article