Respiratory syncytial virus subtypes in children with bronchiolitis: does it correlate with clinical severity?
BMC Infect Dis
; 24(1): 263, 2024 Feb 26.
Article
em En
| MEDLINE
| ID: mdl-38408969
ABSTRACT
BACKGROUND:
In this retrospective study, we aimed to evaluate the factors associated with the severity of respiratory syncytial virus (RSV) bronchiolitis in children aged under 2 years who were admitted to the Children's Hospital of Hebei between June 2018 and January 2019.METHODS:
Sputum samples positive for RSV via multiplex PCR were subtyped using real-time PCR. Data collected included risk factors for disease severity, demographics, microbiology, and outcomes.RESULTS:
Of the 82 children with RSV bronchiolitis, 79 were treated and discharged with improvement, while 3 died. All three patients had underlying medical conditions, including complex congenital heart disease and severe combined immunodeficiency. Further, disease severity was associated with preexisting underlying disease, fever duration, and bacterial co-infection, but not with the RSV subtype.CONCLUSIONS:
Our findings suggest that an appropriate therapeutic regimen should include the detection of bacterial co-infections and the identification of underlying diseases for the effective management of severe RSV bronchiolitis.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Bacterianas
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Bronquiolite
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Vírus Sincicial Respiratório Humano
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Infecções por Vírus Respiratório Sincicial
Limite:
Child
/
Humans
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Infant
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article