Tacrolimus-induced cholestatic hepatotoxicity after renal transplantation: a case report.
J Med Case Rep
; 18(1): 116, 2024 Feb 26.
Article
em En
| MEDLINE
| ID: mdl-38409063
ABSTRACT
BACKGROUND:
In this manuscript, we report a case of tacrolimus-associated hepatotoxicity in a kidney transplant recipient. CASE PRESENTATION In this case report, a 56 years old Arab male patient who received a kidney transplant presented with icterus, weakness, and lethargy two weeks after transplantation and tacrolimus initiation. In laboratory analysis hyperbilirubinemia and a rise in hepatic enzymes were observed. All possible causes of hepatotoxicity were examined. The panel for infectious causes was negative. Drug-induced liver injury was diagnosed. The patient's immunosuppressive regimen was changed to a cyclosporine-based regimen and after this change bilirubin and hepatic enzymes decreased and the patient was discharged without signs and symptoms of hepatitis.CONCLUSION:
It seems that the patient's hyperbilirubinemia was due to tacrolimus, and the patient's bilirubin decreased after stopping tacrolimus.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Colestase
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Transplante de Rim
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Doença Hepática Induzida por Substâncias e Drogas
Limite:
Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article