Report of IRF2BP1 as a novel partner of RARA in variant acute promyelocytic leukemia.
Am J Hematol
; 99(5): 1005-1007, 2024 05.
Article
em En
| MEDLINE
| ID: mdl-38410879
ABSTRACT
IRF2BP1 breaked in the middle of exon 1 at the c.322 position and fused with RARA intron 2 which is located at 3717 bp upstream of its exon 3. The fusion produced a new intron by forming a paired splicing donor GT at 9 bp downstream of RARA breakpoint and acceptor AG at the 5' end of RARA exon 3. The IRF2BP1RARA fusion gene leads a fusion transcript involving IRF2BP1 exon 1 and RARA exon 3, linked by a 9-bp fragment derived from RARA intron 2. The patient with IRF2BP1RARA has same clinical features of APL.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Leucemia Promielocítica Aguda
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article