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Multisensory gamma stimulation promotes glymphatic clearance of amyloid.
Murdock, Mitchell H; Yang, Cheng-Yi; Sun, Na; Pao, Ping-Chieh; Blanco-Duque, Cristina; Kahn, Martin C; Kim, TaeHyun; Lavoie, Nicolas S; Victor, Matheus B; Islam, Md Rezaul; Galiana, Fabiola; Leary, Noelle; Wang, Sidney; Bubnys, Adele; Ma, Emily; Akay, Leyla A; Sneve, Madison; Qian, Yong; Lai, Cuixin; McCarthy, Michelle M; Kopell, Nancy; Kellis, Manolis; Piatkevich, Kiryl D; Boyden, Edward S; Tsai, Li-Huei.
Afiliação
  • Murdock MH; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Yang CY; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Sun N; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA, USA.
  • Pao PC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Blanco-Duque C; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Kahn MC; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Kim T; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Lavoie NS; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Victor MB; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Islam MR; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Galiana F; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Leary N; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Wang S; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Bubnys A; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Ma E; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Akay LA; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Sneve M; Department of Brain and Cognitive Sciences and the Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Qian Y; Departments of Biological Engineering and Brain and Cognitive Sciences, McGovern Institute, Cambridge, MA, USA.
  • Lai C; Koch Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • McCarthy MM; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Kopell N; Departments of Biological Engineering and Brain and Cognitive Sciences, McGovern Institute, Cambridge, MA, USA.
  • Kellis M; Koch Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Piatkevich KD; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Boyden ES; School of Life Sciences, Westlake University, Westlake Laboratory of Life Sciences and Biomedicine, and Westlake Institute for Advanced Study, Hangzhou, China.
  • Tsai LH; Department of Mathematics and Statistics, Boston University, Boston, MA, USA.
Nature ; 627(8002): 149-156, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38418876
ABSTRACT
The glymphatic movement of fluid through the brain removes metabolic waste1-4. Noninvasive 40 Hz stimulation promotes 40 Hz neural activity in multiple brain regions and attenuates pathology in mouse models of Alzheimer's disease5-8. Here we show that multisensory gamma stimulation promotes the influx of cerebrospinal fluid and the efflux of interstitial fluid in the cortex of the 5XFAD mouse model of Alzheimer's disease. Influx of cerebrospinal fluid was associated with increased aquaporin-4 polarization along astrocytic endfeet and dilated meningeal lymphatic vessels. Inhibiting glymphatic clearance abolished the removal of amyloid by multisensory 40 Hz stimulation. Using chemogenetic manipulation and a genetically encoded sensor for neuropeptide signalling, we found that vasoactive intestinal peptide interneurons facilitate glymphatic clearance by regulating arterial pulsatility. Our findings establish novel mechanisms that recruit the glymphatic system to remove brain amyloid.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Líquido Cefalorraquidiano / Líquido Extracelular / Doença de Alzheimer / Ritmo Gama / Sistema Glinfático / Amiloide Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Líquido Cefalorraquidiano / Líquido Extracelular / Doença de Alzheimer / Ritmo Gama / Sistema Glinfático / Amiloide Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article