Lycopodium Alkaloids from Huperzia goebelii.
Chem Biodivers
; 21(4): e202400209, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38419385
ABSTRACT
One new fawcettimine-type Lycopodium alkaloid, hupertimine F (1), together with five known (2-6) Lycopodium alkaloids were isolated from Huperzia goebelii. The structure of 1 was elucidated by 1D and 2D NMR spectra, HRESIMS, and X-ray diffraction. Structurally, 1 represents the fourth example of Lycopodium alkaloids characterized by a 5/5/5/5/6 pentacyclic ring system with a 1-aza-7-oxabicyclo[2.2.1]heptane moiety. These known compoundsâ
2, 3, 5, and 6 were isolated from H. goebelii for the first time. Compoundsâ
1-6 were evaluated for acetylcholinesterase, butyrylcholinesterase and monoamine oxidase B inhibitory activities inâ
vitro.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Huperzia
/
Lycopodium
/
Alcaloides
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article