Joint Exposure to Multiple Air Pollutants, Genetic Susceptibility, and Incident Dementia: A Prospective Analysis in the UK Biobank Cohort.
Int J Public Health
; 69: 1606868, 2024.
Article
em En
| MEDLINE
| ID: mdl-38426188
ABSTRACT
Objectives:
This study aimed to evaluate the joint effects of multiple air pollutants including PM2.5, PM10, NO2, and NOx with dementia and examined the modifying effects of genetic susceptibility.Methods:
This study included 220,963 UK Biobank participants without dementia at baseline. Weighted air pollution score reflecting the joint exposure to multiple air pollutants were constructed by cross-validation analyses, and inverse-variance weighted meta-analyses were performed to create a pooled effect. The modifying effect of genetic susceptibility on air pollution score was assessed by genetic risk score and APOE ε4 genotype.Results:
The HR (95% CI) of dementia for per interquartile range increase of air pollution score was 1.13 (1.07â¼1.18). Compared with the lowest quartile (Q1) of air pollution score, the HR (95% CI) of Q4 was 1.26 (1.13â¼1.40) (P trend = 2.17 × 10-5). Participants with high air pollution score and high genetic susceptibility had higher risk of dementia compared to those with low air pollution score and low genetic susceptibility.Conclusion:
Our study provides evidence that joint exposure to multiple air pollutants substantially increases the risk of dementia, especially among individuals with high genetic susceptibility.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Demência
/
Poluentes Atmosféricos
/
Poluição do Ar
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article