Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis.
Protein Cell
; 15(9): 686-703, 2024 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-38430542
ABSTRACT
Ferroptosis has been recognized as a unique cell death modality driven by excessive lipid peroxidation and unbalanced cellular metabolism. In this study, we established a protein interaction landscape for ferroptosis pathways through proteomic analyses, and identified choline/ethanolamine phosphotransferase 1 (CEPT1) as a lysophosphatidylcholine acyltransferase 3 (LPCAT3)-interacting protein that regulates LPCAT3 protein stability. In contrast to its known role in promoting phospholipid synthesis, we showed that CEPT1 suppresses ferroptosis potentially by interacting with phospholipases and breaking down certain pro-ferroptotic polyunsaturated fatty acid (PUFA)-containing phospholipids. Together, our study reveals a previously unrecognized role of CEPT1 in suppressing ferroptosis.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteômica
/
Ferroptose
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article