Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease.
Eur J Med Chem
; 268: 116263, 2024 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-38432056
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and related variants, are responsible for the devastating coronavirus disease 2019 (COVID-19) pandemic. The SARS-CoV-2 main protease (Mpro) plays a central role in the replication of the virus and represents an attractive drug target. Herein, we report the discovery of novel SARS-CoV-2 Mpro covalent inhibitors, including highly effective compound NIP-22c which displays high potency against several key variants and clinically relevant nirmatrelvir Mpro E166V mutants.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptidomiméticos
/
COVID-19
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article