Reexamining the diverse functions of arginine in biochemistry.
Biochem Biophys Res Commun
; 705: 149731, 2024 04 23.
Article
em En
| MEDLINE
| ID: mdl-38432110
ABSTRACT
Arginine in a free-state and as part of peptides and proteins shows distinct tendency to form clusters. In free-form, it has been found useful in cryoprotection, as a drug excipient for both solid and liquid formulations, as an aggregation suppressor, and an eluent in protein chromatography. In many cases, the mechanisms by which arginine acts in all these applications is either debatable or at least continues to attract interest. It is quite possible that arginine clusters may be involved in many such applications. Furthermore, it is possible that such clusters are likely to behave as intrinsically disordered polypeptides. These considerations may help in understanding the roles of arginine in diverse applications and may even lead to better strategies for using arginine in different situations.
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Base de dados:
MEDLINE
Assunto principal:
Arginina
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article