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Depressive disorder subtypes, depressive symptom clusters, and risk of obesity and diabetes: A systematic review.
Shell, Aubrey L; Crawford, Christopher A; Cyders, Melissa A; Hirsh, Adam T; Stewart, Jesse C.
Afiliação
  • Shell AL; Department of Psychiatry, Indiana University Health, United States of America.
  • Crawford CA; Department of Psychology, Indiana University-Indianapolis, United States of America.
  • Cyders MA; Department of Psychology, Indiana University-Indianapolis, United States of America.
  • Hirsh AT; Department of Psychology, Indiana University-Indianapolis, United States of America.
  • Stewart JC; Department of Psychology, Indiana University-Indianapolis, United States of America. Electronic address: jstew@iupui.edu.
J Affect Disord ; 353: 70-89, 2024 May 15.
Article em En | MEDLINE | ID: mdl-38432462
ABSTRACT

BACKGROUND:

Overlapping but divided literatures suggest certain depression facets may pose greater obesity and diabetes risk than others. Our objectives were to integrate the major depressive disorder (MDD) subtype and depressive symptom cluster literatures and to clarify which facets are associated with the greatest cardiometabolic disease risk.

METHODS:

We conducted a systematic review of published studies examining associations of ≥2 MDD subtypes or symptom clusters with obesity or diabetes risk outcomes. We report which facets the literature is "in favor" of (i.e., having the strongest or most consistent results).

RESULTS:

Forty-five articles were included. Of the MDD subtype-obesity risk studies, 14 were in favor of atypical MDD, and 8 showed similar or null associations across subtypes. Of the symptom cluster-obesity risk studies, 5 were in favor of the somatic cluster, 1 was in favor of other clusters, and 5 were similar or null. Of the MDD subtype-diabetes risk studies, 7 were in favor of atypical MDD, 3 were in favor of other subtypes, and 5 were similar or null. Of the symptom cluster-diabetes risk studies, 7 were in favor of the somatic cluster, and 5 were similar or null.

LIMITATIONS:

Limitations in study design, sample selection, variable measurement, and analytic approach in these literatures apply to this review.

CONCLUSIONS:

Atypical MDD and the somatic cluster are most consistently associated with obesity and diabetes risk. Future research is needed to establish directionality and causality. Identifying the depression facets conferring the greatest risk could improve cardiometabolic disease risk stratification and prevention programs.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior / Diabetes Mellitus / Obesidade Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior / Diabetes Mellitus / Obesidade Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article