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InflammamiRs in focus: Delivery strategies and therapeutic approaches.
Akkaya-Ulum, Yeliz Z; Sen, Basak; Akbaba, Tayfun Hilmi; Balci-Peynircioglu, Banu.
Afiliação
  • Akkaya-Ulum YZ; Department of Medical Biology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  • Sen B; Department of Medical Biology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  • Akbaba TH; Department of Medical Biology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
  • Balci-Peynircioglu B; Department of Medical Biology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
FASEB J ; 38(5): e23528, 2024 Mar 15.
Article em En | MEDLINE | ID: mdl-38441434
ABSTRACT
microRNAs (miRNAs) are small non-protein-coding RNAs which are essential regulators of host genome expression at the post-transcriptional level. There is evidence of dysregulated miRNA expression patterns in a wide variety of diseases, such as autoimmune and inflammatory conditions. These miRNAs have been termed "inflammamiRs." When working with miRNAs, the method followed, the approach to treat or diagnosis, and the selected biological material are very crucial. Demonstration of the role of miRNAs in particular disease phenotypes facilitates their evaluation as potential and effective therapeutic tools. A growing number of reports suggest the significant utility of miRNAs and other small RNA drugs in clinical medicine. Most miRNAs seem promising therapeutic options, but some features associated with miRNA therapy like off-target effect, effective dosage, or differential delivery methods, mainly caused by the short target's sequence, make miRNA therapies challenging. In this review, we aim to discuss some of the inflammamiRs in diseases associated with inflammatory pathways and the challenge of identifying the most potent therapeutic candidates and provide a perspective on achieving safe and targeted delivery of miRNA therapeutics. We also discuss the status of inflammamiRs in clinical trials.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs Idioma: En Ano de publicação: 2024 Tipo de documento: Article