Mediastinal Germ-cell Tumors Relapse in a Male With Klinefelter Syndrome. Is Longer Surveillance Needed?
J Pediatr Hematol Oncol
; 46(3): e248-e250, 2024 04 01.
Article
em En
| MEDLINE
| ID: mdl-38446472
ABSTRACT
Germ cell tumors (GCTs) are a heterogeneous group of pediatric cancers. In up to one-third of male patients, a primary mediastinal location is associated with the presence of Klinefelter syndrome (KS). We describe a case of mediastinal GCT in a patient, with unacknowledged KS, that presented a relapse 7 years from diagnosis, that is, 2 years after the end of the follow-up program usually recommended for patients with GCT. There are no recommendations for screening for KS in patients with mediastinal GCT and there are no specific guidelines for surveillance of GCT in KS patients. Our experience suggests that KS should be suspected in patients with mediastinal GCT, and a longer follow-up plan should be implemented when GCT occurs in patients with KS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Embrionárias de Células Germinativas
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Síndrome de Klinefelter
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Neoplasias do Mediastino
Limite:
Child
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Humans
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Male
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article