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The association of milk and multiple food avoidance with growth parameters in infants and children.
Sackesen, Cansin; Buyuktiryaki, Betul; Gokce, Tugba; Gogebakan, Emre; Gundogdu, Beliz Su; Eltan, Sevgi Bilgic; Karakoc-Aydiner, Elif; Yilmaz, Ebru Arik; Can, Ceren; Cengiz, Hilal; Unlugedik, Ozlem; Celik, Nevin; Incir, Said; Mutlu, Gul Yesiltepe; Yildirim, Damla; Ozel, Hulya Gokmen; Hatun, Sukru.
Afiliação
  • Sackesen C; Division of Pediatric Allergy, Koc University School of Medicine, Istanbul, Turkey. Electronic address: csackesen@yahoo.com.
  • Buyuktiryaki B; Division of Pediatric Allergy, Koc University School of Medicine, Istanbul, Turkey.
  • Gokce T; Division of Pediatric Endocrinology, Koc University School of Medicine, Istanbul, Turkey.
  • Gogebakan E; Koc University School of Medicine, Istanbul, Turkey.
  • Gundogdu BS; Koc University School of Medicine, Istanbul, Turkey.
  • Eltan SB; Division of Pediatric Immunology and Allergy, Marmara University School of Medicine, Istanbul, Turkey.
  • Karakoc-Aydiner E; Division of Pediatric Immunology and Allergy, Marmara University School of Medicine, Istanbul, Turkey.
  • Yilmaz EA; Division of Pediatric Immunology and Allergy, Pamukkale University School of Medicine, Denizli, Turkey.
  • Can C; Pediatric Allergy and Immunology Clinic, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
  • Cengiz H; Department of Pediatrics, Koc University School of Medicine, Istanbul, Turkey.
  • Unlugedik O; Department of Pediatrics, Koc University School of Medicine, Istanbul, Turkey.
  • Celik N; Department of Pediatrics, Koc University School of Medicine, Istanbul, Turkey.
  • Incir S; Department of Biochemistry, Koc University School of Medicine, Istanbul, Turkey.
  • Mutlu GY; Division of Pediatric Endocrinology, Koc University School of Medicine, Istanbul, Turkey.
  • Yildirim D; Nutrition and Dietetics Department, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey.
  • Ozel HG; Nutrition and Dietetics Department, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey.
  • Hatun S; Division of Pediatric Endocrinology, Koc University School of Medicine, Istanbul, Turkey.
Ann Allergy Asthma Immunol ; 132(6): 745-751.e2, 2024 06.
Article em En | MEDLINE | ID: mdl-38447665
ABSTRACT

BACKGROUND:

Recent studies reported that strict avoidance of milk products in cow's milk allergy (CMA) affects growth and bone turnover, causing negative calcium balance and changes in bone metabolism.

OBJECTIVE:

To investigate biochemical parameters to predict bone turnover and its relations with height and weight measurements and nutritional intake.

METHODS:

Height, weight, and body mass index z scores were plotted for age according to the World Health Organization. A 3-consecutive day food record was analyzed for nutritional values of foods. The blood levels of calcium, phosphorus, alkaline phosphatase, vitamin D, and parathyroid hormone (PTH) were determined.

RESULTS:

The study included 69 controls, 66 children with isolated CMA, and 59 children with multiple food allergy (FA). The z scores for weight, height, and body mass index were lower in isolated CMA and multiple FA groups than controls (P < .001, P = .004, and P = .002, respectively). The nutritional intakes of protein, fat, carbohydrates, vitamins B2 and B12, niacin, calcium, and phosphorus were significantly lower in isolated CMA and multiple FA than controls. In infants (≤2 years of age), although blood calcium level was in normal range, it was significantly lower in isolated CMA and multiple FA than in controls (P < .001). In children older than 2 years, PTH level was significantly higher in isolated CMA and multiple FA groups than in controls (P = .003).

CONCLUSION:

Our study revealed that children with isolated CMA and multiple FA had a high nutrition gap, growth deceleration, and unbalanced bone metabolism, as illustrated by low blood calcium and elevated PTH levels.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cálcio / Hipersensibilidade a Leite Limite: Animals / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cálcio / Hipersensibilidade a Leite Limite: Animals / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article