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Supplementing Glucose Intake Reverses the Inflammation Induced by a High-Fat Diet by Increasing the Expression of Siglec-E Ligands on Erythrocytes.
Liu, Hongmei; Li, Jin; Wu, Niting; She, Yuanting; Luo, Yadan; Huang, Yan; Quan, Hongyu; Fu, Wenying; Li, Xiaohui; Zeng, Dongfeng; Jia, Yi.
Afiliação
  • Liu H; Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Army Medical University, Chongqing, 400038, China.
  • Li J; Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Army Medical University, Chongqing, 400038, China.
  • Wu N; Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Army Medical University, Chongqing, 400038, China.
  • She Y; Department of Haematology, Daping Hospital of Army Medical University, Chongqing, 400042, China.
  • Luo Y; Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Army Medical University, Chongqing, 400038, China.
  • Huang Y; Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Army Medical University, Chongqing, 400038, China.
  • Quan H; Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Army Medical University, Chongqing, 400038, China.
  • Fu W; Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Army Medical University, Chongqing, 400038, China.
  • Li X; Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Army Medical University, Chongqing, 400038, China.
  • Zeng D; Department of Haematology, Daping Hospital of Army Medical University, Chongqing, 400042, China. dongfengzeng@hotmail.com.
  • Jia Y; Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Army Medical University, Chongqing, 400038, China. jy@tmmu.edu.cn.
Inflammation ; 47(2): 609-625, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38448631
ABSTRACT
Siglec-9/E is a cell surface receptor expressed on immune cells and can be activated by sialoglycan ligands to play an immunosuppressive role. Our previous study showed that increasing the expression of Siglec-9 (the human paralog of mouse Siglec-E) ligands maintains functionally quiescent immune cells in the bloodstream, but the biological effects of Siglec-9 ligand alteration on atherogenesis were not further explored. In the present study, we demonstrated that the atherosclerosis risk factor ox-LDL or a high-fat diet could decrease the expression of Siglec-9/E ligands on erythrocytes. Increased expression of Siglec-E ligands on erythrocytes caused by dietary supplementation with glucose (20% glucose) had anti-inflammatory effects, and the mechanism was associated with glucose intake. In high-fat diet-fed apoE-/- mice, glucose supplementation decreased the area of atherosclerotic lesions and peripheral inflammation. These data suggested that increased systemic inflammation is attenuated by increasing the expression of Siglec-9/E ligands on erythrocytes. Therefore, Siglec-9/E ligands might be valuable targets for atherosclerosis therapy.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antígenos de Diferenciação de Linfócitos B / Eritrócitos / Dieta Hiperlipídica / Lectinas Semelhantes a Imunoglobulina de Ligação ao Ácido Siálico / Glucose / Inflamação Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antígenos de Diferenciação de Linfócitos B / Eritrócitos / Dieta Hiperlipídica / Lectinas Semelhantes a Imunoglobulina de Ligação ao Ácido Siálico / Glucose / Inflamação Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article