HLA Gene Polymorphisms in Romanian Patients with Chronic Lymphocytic Leukemia.
Genet Res (Camb)
; 2024: 8852876, 2024.
Article
em En
| MEDLINE
| ID: mdl-38449839
ABSTRACT
Materials and Methods:
This study included 66 patients with CLL, diagnosed between 2020 and 2022, and 100 healthy controls. HLA class I and class II genes (HLA-A/B/C, HLA-DQA1/DQB1/DPA1/DPB1, and HLA-DRB1/3/4/5) were investigated using next-generation sequencing technology.Results:
Several HLA alleles were strongly associated with CLL. The most important finding was that HLA-DRB1∗040201 (p=0.001, OR = 1.05) and HLA-DRB3∗020101 (p=0.009, OR = 1.03) have a predisposing role in CLL development. Moreover, we identified that HLA-A∗240201 0.01 (p=0.01, OR = 0.38), HLA-DQA1∗050501 (p=0.01, OR = 0.56), HLA-DQB1∗030201 (p=0.03, OR = 0.40), and HLA-DRB4∗010301 (p=0.03, OR = 0.54 alleles have protective roles. Correlations between HLA expression and gender showed that women had a higher expression of protective HLA alleles when compared to men.Conclusions:
Our data are the first to indicate that in Romanian patients with CLL, the HLA-A∗240201 and HLA-DQA1∗050501 alleles have a protective role against CLL development, whereas HLA-DRB1∗040201 and HLA-DRB3∗020101alleles are positively associated with CLL.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Leucemia Linfocítica Crônica de Células B
Limite:
Female
/
Humans
/
Male
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article