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Axonal self-sorting without target guidance in Drosophila visual map formation.
Agi, Egemen; Reifenstein, Eric T; Wit, Charlotte; Schneider, Teresa; Kauer, Monika; Kehribar, Melinda; Kulkarni, Abhishek; von Kleist, Max; Hiesinger, P Robin.
Afiliação
  • Agi E; Division of Neurobiology, Free University of Berlin, 14195 Berlin, Germany.
  • Reifenstein ET; Department of Mathematics, Free University of Berlin, 14195 Berlin, Germany.
  • Wit C; Division of Neurobiology, Free University of Berlin, 14195 Berlin, Germany.
  • Schneider T; Division of Neurobiology, Free University of Berlin, 14195 Berlin, Germany.
  • Kauer M; Division of Neurobiology, Free University of Berlin, 14195 Berlin, Germany.
  • Kehribar M; Division of Neurobiology, Free University of Berlin, 14195 Berlin, Germany.
  • Kulkarni A; Division of Neurobiology, Free University of Berlin, 14195 Berlin, Germany.
  • von Kleist M; Department of Mathematics, Free University of Berlin, 14195 Berlin, Germany.
  • Hiesinger PR; Division of Neurobiology, Free University of Berlin, 14195 Berlin, Germany.
Science ; 383(6687): 1084-1092, 2024 Mar 08.
Article em En | MEDLINE | ID: mdl-38452066
ABSTRACT
The idea of guidance toward a target is central to axon pathfinding and brain wiring in general. In this work, we show how several thousand axonal growth cones self-pattern without target-dependent guidance during neural superposition wiring in Drosophila. Ablation of all target lamina neurons or loss of target adhesion prevents the stabilization but not the development of the pattern. Intravital imaging at the spatiotemporal resolution of growth cone dynamics in intact pupae and data-driven dynamics simulations reveal a mechanism by which >30,000 filopodia do not explore potential targets, but instead simultaneously generate and navigate a dynamic filopodial meshwork that steers growth directions. Hence, a guidance mechanism can emerge from the interactions of the axons being guided, suggesting self-organization as a more general feature of brain wiring.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cones de Crescimento / Drosophila melanogaster / Orientação de Axônios Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cones de Crescimento / Drosophila melanogaster / Orientação de Axônios Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article