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Advanced Characterization Methodology to Unravel the Biodegradability of Metal-Organic Framework Nanoparticles in Extremely Diluted Conditions.
Christodoulou, Ioanna; Patriarche, Gilles; Serre, Christian; Boissiére, Cédric; Gref, Ruxandra.
Afiliação
  • Christodoulou I; Institut des Sciences Moléculaires d'Orsay (ISMO), Université Paris-Saclay, CNRS UMR 8214, 91405 Orsay, France.
  • Patriarche G; Centre de Nanosciences et de Nanotechnologies (C2N), Université Paris-Saclay, CNRS UMR 9001, 91120 Palaiseau, France.
  • Serre C; Institut des Matériaux Poreux de Paris, Ecole Normale Supérieure, ESPCI Paris, CNRS, PSL University, 75005 Paris, France.
  • Boissiére C; Laboratoire de Chimie de la Matière Condensée de Paris (LCMCP), Sorbonne Université, CNRS, Collège de France, 75005 Paris, France.
  • Gref R; Institut des Sciences Moléculaires d'Orsay (ISMO), Université Paris-Saclay, CNRS UMR 8214, 91405 Orsay, France.
ACS Appl Mater Interfaces ; 16(11): 14296-14307, 2024 Mar 20.
Article em En | MEDLINE | ID: mdl-38452344
ABSTRACT
Porous iron(III) carboxylate metal-organic frameworks (MIL-100; MIL stands for Material of Institute Lavoisier) of submicronic size (nanoMOFs) have attracted a growing interest in the field of drug delivery due to their high drug payloads, excellent entrapment efficiencies, biodegradable character, and poor toxicity. However, only a few studies have dealt with the nanoMOF degradation mechanism, which is key to their biological applications. Complementary methods have been used here to investigate the degradation mechanism of Fe-based nanoMOFs under neutral or acidic conditions and in the presence of albumin. High-resolution STEM-HAADF coupled with energy-dispersive X-ray spectroscopy enabled the monitoring of the crystalline organization and elemental distribution during degradation. NanoMOFs were also deposited onto silicon substrates by dip-coating, forming stable thin films of high optical quality. The mean film thickness and structural changes were further monitored by IR ellipsometry, approaching the "sink conditions" occurring in vivo. This approach is essential for the successful design of biocompatible nano-vectors under extreme diluted conditions. It was revealed that while the presence of a protein coating layer did not impede the degradation process, the pH of the medium in contact with the nanoMOFs played a major role. The degradation of nanoMOFs occurred to a larger extent under neutral conditions, rapidly and homogeneously within the crystalline matrices, and was associated with the departure of their constitutive organic ligand. Remarkably, the nanoMOFs' particles maintained their global morphology during degradation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanopartículas / Estruturas Metalorgânicas Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanopartículas / Estruturas Metalorgânicas Idioma: En Ano de publicação: 2024 Tipo de documento: Article