Dominance and multi-locus interaction.
Trends Genet
; 40(4): 364-378, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38453542
ABSTRACT
Dominance is usually considered a constant value that describes the relative difference in fitness or phenotype between heterozygotes and the average of homozygotes at a focal polymorphic locus. However, the observed dominance can vary with the genetic background of the focal locus. Here, alleles at other loci modify the observed phenotype through position effects or dominance modifiers that are sometimes associated with pathogen resistance, lineage, sex, or mating type. Theoretical models have illustrated how variable dominance appears in the context of multi-locus interaction (epistasis). Here, we review empirical evidence for variable dominance and how the observed patterns may be captured by proposed epistatic models. We highlight how integrating epistasis and dominance is crucial for comprehensively understanding adaptation and speciation.
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Base de dados:
MEDLINE
Assunto principal:
Epistasia Genética
/
Modelos Genéticos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article