Total Synthesis of (±)-Rubriflordilactone A.

ABSTRACT

A new and efficient synthesis of rubriflordilactone A has been realized. The key transformations include the following (1) an intramolecular Prins cyclization to establish the seven-membered ring containing two contiguous stereocenters; (2) a Mukaiyama hydration/oxa-Michael cascade to construct the B-ring; and (3) an unprecedented stereocontrol intermolecular o-QM type [4 + 2]-cycloaddition to rapidly assemble core structure of rubriflordilactone A.