Strategies for Inducing and Validating Zinc Deficiency and Zinc Repletion.
bioRxiv
; 2024 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-38463970
ABSTRACT
Given the growing interest in the role of zinc in the onset and progression of diseases, there is a crucial demand for reliable methods to modulate zinc homeostasis. Using a dietary approach, we provide validated strategies to alter whole-body zinc in mice, applicable across species. For confirmation of zinc status, animal growth rates as well as plasma and urine zinc levels were evaluated. The accessible and cost-effective methodology outlined will increase scientific rigor, ensuring reproducibility in studies exploring the impact of zinc deficiency and repletion on the onset and progression of diseases.
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MEDLINE
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En
Ano de publicação:
2024
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Article