Cardiovascular risk in women with nonclassical congenital adrenal hyperplasia.
J Clin Endocrinol Metab
; 2024 Mar 11.
Article
em En
| MEDLINE
| ID: mdl-38466890
ABSTRACT
CONTEXT The outcomes related to cardiovascular risk (CVR) in patients with nonclassical form of congenital adrenal hyperplasia (NCAH) are unknown, especially those related to therapeutic options, including low doses of glucocorticoids (GCs) or oral contraceptive pills. OBJECTIVES:
to analyze CVR by markers of atherosclerosis in females with nonclassical form according to therapeutic options. DESIGN ANDSETTING:
a cross-sectional study at a tertiary center. PATIENTS ANDMETHODS:
Forty-seven females with NCAH (33.4 ± 10 years) were subdivided into G1 (n = 28) treated with dexamethasone (0.14 ± 0.05â mg/m2/day); G2 (n = 19) with oral contraceptive pills; and G3 (30 matched controls). CVR was analyzed through serum lipids, HOMA-IR, inflammatory cytokines levels and quantitative image evaluations (pulse wave velocity-PWV, endothelial function by flow mediated dilatation-FMD, carotid intima media thickness-CIMT and visceral fat-VAT by abdominal tomography.RESULTS:
There were no statistically significant differences in BMI, HOMA-IR, HDL-cholesterol, or triglyceride levels among groups (p > 0.05). Serum interleukin-6 levels ââwere higher in G1 than in G2 (p = 0.048), and interleukin-8 levels were higher in G1 than in G2/3 (p = 0.008). There were no statistically significant differences in VAT, PWV, FMD or CIMT among groups (p > 0.05). In multivariable regression analysis, there was no statistically significant association between glucocorticoid dose and evaluated outcomes.CONCLUSION:
Adult females with NCAH did not show increased CVR using methodologies for detection of precocious atherosclerosis. Although patients receiving dexamethasone therapy had increased IL-6 and 8 levels, these data were not associated with radiological markers of atherosclerosis. Our cohort was composed of young adults and should be reevaluated in a long-term follow-up.
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MEDLINE
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En
Ano de publicação:
2024
Tipo de documento:
Article