Your browser doesn't support javascript.
loading
An antiviral oligomerized linear thiopeptide with a nitrile group from soil-derived Streptomyces sp. CPCC 203702.
Guo, Zhe; Zhang, Dewu; Wang, Yujia; Bai, Jinglin; Hu, Jun; Cen, Shan; Yu, Liyan.
Afiliação
  • Guo Z; China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 People's Republic of China zhangdewuever@163.com yly@cpcc.ac.cn.
  • Zhang D; China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 People's Republic of China zhangdewuever@163.com yly@cpcc.ac.cn.
  • Wang Y; Division for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms Beijing 100050 People's Republic of China.
  • Bai J; China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 People's Republic of China zhangdewuever@163.com yly@cpcc.ac.cn.
  • Hu J; Division for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms Beijing 100050 People's Republic of China.
  • Cen S; China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 People's Republic of China zhangdewuever@163.com yly@cpcc.ac.cn.
  • Yu L; Division for Medicinal Microorganisms Related Strains, CAMS Collection Center of Pathogenic Microorganisms Beijing 100050 People's Republic of China.
RSC Adv ; 14(12): 8260-8263, 2024 Mar 06.
Article em En | MEDLINE | ID: mdl-38469195
ABSTRACT
A new linear thiopeptide, bernitrilecin (1), was isolated from Streptomyces sp. CPCC 203702. Compound 1 is the first example of a nitrile-bearing thiopeptide. Its structure and absolute configuration were elucidated by extensive analysis of spectroscopic data and Marfey's method. The biosynthesis of the nitrile unit for 1 was proposed to be through oxidations, decarboxylation, and dehydration. Compound 1 exhibited significant anti-influenza A virus activity with the IC50 value of 16.7 µM.
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article