Mitochondrial Dysfunction and Metabolic Reprogramming in Obesity and Asthma.
Int J Mol Sci
; 25(5)2024 Mar 03.
Article
em En
| MEDLINE
| ID: mdl-38474191
ABSTRACT
Mitochondrial dysfunction and metabolic reprogramming have been extensively studied in many disorders ranging from cardiovascular to neurodegenerative disease. Obesity has previously been associated with mitochondrial fragmentation, dysregulated glycolysis, and oxidative phosphorylation, as well as increased reactive oxygen species production. Current treatments focus on reducing cellular stress to restore homeostasis through the use of antioxidants or alterations of mitochondrial dynamics. This review focuses on the role of mitochondrial dysfunction in obesity particularly for those suffering from asthma and examines mitochondrial transfer from mesenchymal stem cells to restore function as a potential therapy. Mitochondrial targeted therapy to restore healthy metabolism may provide a unique approach to alleviate dysregulation in individuals with this unique endotype.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Doenças Neurodegenerativas
/
Doenças Mitocondriais
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article