Synthesis and Biological Evaluation of New Dihydrofuro[3,2-b]piperidine Derivatives as Potent α-Glucosidase Inhibitors.
Molecules
; 29(5)2024 Mar 06.
Article
em En
| MEDLINE
| ID: mdl-38474691
ABSTRACT
Inhibition of glycoside hydrolases has widespread application in the treatment of diabetes. Based on our previous findings, a series of dihydrofuro[3,2-b]piperidine derivatives was designed and synthesized from D- and L-arabinose. Compounds 32 (IC50 = 0.07 µM) and 28 (IC50 = 0.5 µM) showed significantly stronger inhibitory potency against α-glucosidase than positive control acarbose. The study of the structure-activity relationship of these compounds provides a new clue for the development of new α-glucosidase inhibitors.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acarbose
/
Inibidores de Glicosídeo Hidrolases
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article