Racial and ethnic differences in the association between depressive symptoms and cognitive outcomes in older adults: Findings from KHANDLE and STAR.
Alzheimers Dement
; 20(5): 3147-3156, 2024 05.
Article
em En
| MEDLINE
| ID: mdl-38477489
ABSTRACT
INTRODUCTION:
Depressive symptoms are associated with higher risk of dementia, but how they impact cognition in diverse populations is unclear.METHODS:
Asian, Black, Latino, or White participants (n = 2227) in the Kaiser Healthy Aging and Diverse Life Experiences (age 65+) and the Study of Healthy Aging in African Americans (age 50+) underwent up to three waves of cognitive assessments over 4 years. Multilevel models stratified by race/ethnicity were used to examine whether depressive symptoms were associated with cognition or cognitive decline and whether associations differed by race/ethnicity.RESULTS:
Higher depressive symptoms were associated with lower baseline verbal episodic memory scores (-0.06, 95% CI -0.12, -0.01; -0.15, 95% CI -0.25, -0.04), and faster decline annually in semantic memory (-0.04, 95% CI -0.07, -0.01; -0.10, 95% CI -0.15, -0.05) for Black and Latino participants. Depressive symptoms were associated with lower baseline but not decline in executive function.DISCUSSION:
Depressive symptoms were associated with worse cognitive outcomes, with some evidence of heterogeneity across racial/ethnic groups. HIGHLIGHTS We examined whether baseline depressive symptoms were differentially associated with domain-specific cognition or cognitive decline by race/ethnicity. Depressive symptoms were associated with worse cognitive scores for all racial/ethnic groups across different domains examined. Higher depressive symptoms were associated with faster cognitive decline for semantic memory for Black and Latino participants. The results suggest a particularly harmful association between depressive symptoms and cognition in certain racial/ethnic groups.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Depressão
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article