Effects of Overweight on Risk of Thyroid Nodules in Children and Adolescents: The Fukushima Health Management Survey.

Ohira, Tetsuya; Nagao, Masanori; Hayashi, Fumikazu; Shimura, Hiroki; Suzuki, Satoru; Yasumura, Seiji; Takahashi, Hideto; Suzuki, Satoshi; Iwadate, Manabu; Hosoya, Mitsuaki; Sakai, Akira; Ishikawa, Tetsuo; Furuya, Fumihiko; Suzuki, Shinichi; Yokoya, Susumu; Ohto, Hitoshi; Kamiya, Kenji

Ohira, Tetsuya; Nagao, Masanori; Hayashi, Fumikazu; Shimura, Hiroki; Suzuki, Satoru; Yasumura, Seiji; Takahashi, Hideto; Suzuki, Satoshi; Iwadate, Manabu; Hosoya, Mitsuaki; Sakai, Akira; Ishikawa, Tetsuo; Furuya, Fumihiko; Suzuki, Shinichi; Yokoya, Susumu; Ohto, Hitoshi; Kamiya, Kenji.

Afiliação

Ohira T; Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan.
Nagao M; Department of Epidemiology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Hayashi F; Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan.
Shimura H; Department of Epidemiology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Suzuki S; Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan.
Yasumura S; Department of Epidemiology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Takahashi H; Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan.
Suzuki S; Department of Laboratory Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan.
Iwadate M; Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan.
Hosoya M; Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan.
Sakai A; Department of Public Health, Fukushima Medical University School of Medicine, Fukushima, Japan.
Ishikawa T; Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan.
Furuya F; Teikyo Heisei University, School of Pharmacy, Center for Education and Research in Social Pharmacy, Tokyo, Japan.
Suzuki S; Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan.
Yokoya S; Department of Thyroid and Endocrinology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Ohto H; Department of Thyroid and Endocrinology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Kamiya K; Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan.

J Clin Endocrinol Metab ; 2024 Mar 13.

Article em En | MEDLINE | ID: mdl-38477491

ABSTRACT

ABSTRACT

CONTEXT Examining how overweight/obesity impacts thyroid nodule development in children and adolescents by sex and age can speculate on the mechanism.

OBJECTIVE:

We examined whether overweight in children and adolescents are associated with thyroid nodule development by sex and age.

DESIGN:

Approximately 300,000 participants who underwent thyroid ultrasonography in the Fukushima Health Management Survey after a nuclear accident were enrolled. Those without nodules in the initial two examinations (1-3 and 4-5 years postaccident) were prospectively assessed for nodule development in the third examination (6-7 years postaccident) relative to baseline overweight status, with an average follow-up of 4.2 years.

SETTING:

A population-based prospective cohort study.

PARTICIPANTS:

The first and second thyroid examinations involved 299,939 and 237,691 participants, respectively, excluding those with thyroid nodules. After the third examination, 184,519 participants were finalized for analysis. MAIN OUTCOME

MEASURES:

Multivariable-adjusted odds ratios of new detected thyroid nodules for overweight participants compared with normal-weight participants.

RESULTS:

New thyroid nodules were detected in 660 participants. Being overweight was positively associated with thyroid nodules. The adjusted odds ratio (95% confidence interval) of thyroid nodules for overweight participants compared with other participants was 1.27 (1.04-1.57). Additionally, the multivariable-adjusted odds ratios for males and females with overweight were 1.21 and 1.32, respectively, and those for different age groups (0-9, 10-14, and 15-19 years) ranged from 1.17 to 1.75.