Short-term exposure to cigarette smoke upregulates cathepsin S and alters expression of tight junction ZO-1.
Biochimie
; 2024 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-38494107
ABSTRACT
A long-term exposure to cigarette smoke (CS) alters the integrity of airway epithelial barrier, contributes to lung dysfunction, and elicits the expression and activity of lung cathepsin S (CatS), a cysteine protease that participates in the remodeling of connective tissue and cell junctions. Here, we observed that a short-term (4 days) exposure of mice to CS increased the expression and activity of CatS, while the expression level of zonula occludens 1 (ZO-1), an epithelial tight junction protein that stabilizes barrier assembly, was reduced in lung tissue lysates. Present data support that proteolytically active CatS may contribute to the defect of ZO-1 in CS-exposed mice.
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MEDLINE
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En
Ano de publicação:
2024
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Article