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Tumor immune escape by autotaxin: keeping eosinophils at bay.
Matas-Rico, Elisa; Moolenaar, Wouter H.
Afiliação
  • Matas-Rico E; Department of Cell Biology, Genetics and Physiology, University of Málaga, Málaga, Spain.
  • Moolenaar WH; Division of Biochemistry, the Netherlands Cancer Institute, Plesmanlaan, Amsterdam. Electronic address: w.moolenaar@nki.nl.
Trends Cancer ; 10(4): 283-285, 2024 Apr.
Article em En | MEDLINE | ID: mdl-38494373
ABSTRACT
Secreted autotaxin (ATX) promotes tumor progression by producing the pleiotropic lipid mediator lysophosphatidic acid (LPA). In a recent Nature Cancer paper, Bhattacharyya et al. show that ATX/LPA signaling suppresses CCL11-driven infiltration of eosinophils into the pancreatic tumor microenvironment to facilitate tumor progression, thus revealing a new ATX-mediated immune escape mechanism and highlighting the antitumor potential of eosinophils.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Evasão Tumoral / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Evasão Tumoral / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article