Twice-walk strategy based on three-dimensional DNA walking machine driven by duplex-specific nuclease.
Chem Commun (Camb)
; 60(28): 3778-3781, 2024 Apr 02.
Article
em En
| MEDLINE
| ID: mdl-38494893
ABSTRACT
A twice-walk strategy based on a three-dimensional (3D) cleat-equipped DNA walking machine with a high signal amplification efficiency was investigated for ultrasensitive detection of miRNA. Impressively, addition of duplex-specific nuclease (DSN) just once drove the twice-walk strategy, making the strategy simpler. With the advantages of being simple, rapid and ultrasensitive, the biosensor offers potential for use in early clinical diagnosis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Técnicas Biossensoriais
/
MicroRNAs
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article