Tricarboxylic acid cycle metabolites: new players in macrophage.
Inflamm Res
; 73(4): 531-539, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38498178
ABSTRACT
Metabolic remodeling is a key feature of macrophage activation and polarization. Recent studies have demonstrated the role of tricarboxylic acid (TCA) cycle metabolites in the innate immune system. In the current review, we summarize recent advances in the metabolic reprogramming of the TCA cycle during macrophage activation and polarization and address the effects of these metabolites in modulating macrophage function. Deciphering the crosstalk between the TCA cycle and the immune response might provide novel potential targets for the intervention of immune reactions and favor the development of new strategies for the treatment of infection, inflammation, and cancer.
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Base de dados:
MEDLINE
Assunto principal:
Ciclo do Ácido Cítrico
/
Macrófagos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article