Tissue-Resident Macrophages in Solid Organ Transplantation: Harmful or Protective?
J Immunol
; 212(7): 1051-1061, 2024 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-38498808
ABSTRACT
Transplanted organs carry donor immune cells into the recipient, the majority of which are tissue-resident macrophages (TRMs). The role they play in guiding the fate of the transplanted organ toward acceptance or rejection remains elusive. TRMs originate from both embryonic and bone marrow-derived precursors. Embryo-derived TRMs retain the embryonic capability to proliferate, so they are able to self-renew and, theoretically, persist for extended periods of time after transplantation. Bone marrow-derived TRMs do not proliferate and must constantly be replenished by adult circulating monocytes. Recent studies have aimed to clarify the different roles and interactions between donor TRMs, recipient monocytes, and monocyte-derived macrophages (MFs) after organ transplantation. This review aims to shed light on how MFs affect the fate of a transplanted organ by differentiating between the role of donor TRMs and that of MFs derived from graft infiltrating monocytes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transplante de Órgãos
/
Macrófagos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article