Competition quenching strategies reduce antibiotic tolerance in polymicrobial biofilms.
NPJ Biofilms Microbiomes
; 10(1): 23, 2024 Mar 19.
Article
em En
| MEDLINE
| ID: mdl-38503782
ABSTRACT
Bacteria typically live in dense communities where they are surrounded by other species and compete for a limited amount of resources. These competitive interactions can induce defensive responses that also protect against antimicrobials, potentially complicating the antimicrobial treatment of pathogens residing in polymicrobial consortia. Therefore, we evaluate the potential of alternative antivirulence strategies that quench this response to competition. We test three competition quenching approaches (i) interference with the attack mechanism of surrounding competitors, (ii) inhibition of the stress response systems that detect competition, and (iii) reduction of the overall level of competition in the community by lowering the population density. We show that either strategy can prevent the induction of antimicrobial tolerance of Salmonella Typhimurium in response to competitors. Competition quenching strategies can thus reduce tolerance of pathogens residing in polymicrobial communities and could contribute to the improved eradication of these pathogens via traditional methods.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anti-Infecciosos
/
Antibacterianos
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article