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Venlafaxine-Associated Rhabdomyolysis: A Literature Review.
Ren, Jieru; Wang, Ying; Nie, Jing; Sun, Lei; Wu, Huina; Li, Yamei; Wu, Jiyong.
Afiliação
  • Ren J; From the Department of Pharmacy, Shandong Second Provincial General Hospital, Jinan.
  • Wang Y; University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, Shandong, China.
  • Nie J; From the Department of Pharmacy, Shandong Second Provincial General Hospital, Jinan.
  • Sun L; From the Department of Pharmacy, Shandong Second Provincial General Hospital, Jinan.
  • Wu H; From the Department of Pharmacy, Shandong Second Provincial General Hospital, Jinan.
  • Li Y; From the Department of Pharmacy, Shandong Second Provincial General Hospital, Jinan.
  • Wu J; From the Department of Pharmacy, Shandong Second Provincial General Hospital, Jinan.
J Clin Psychopharmacol ; 44(3): 297-301, 2024.
Article em En | MEDLINE | ID: mdl-38506608
ABSTRACT

PURPOSE:

This systematic review aimed to investigate the clinical manifestations and characteristics of venlafaxine-associated rhabdomyolysis.

METHODS:

A systematic search was conducted in PubMed, Elsevier, Science Direct, Embase, Springer Link, Wiley Online Library, CNKI, and Wanfang databases from the date of database inception to January 2023. Previously reported cases of venlafaxine-associated rhabdomyolysis were identified, and relevant data from these cases were collected for descriptive statistical analysis. Cases that met the inclusion criteria were evaluated to determine the correlation between adverse reactions and venlafaxine.

RESULTS:

A total of 12 patients with venlafaxine-associated rhabdomyolysis were included. None of these patients had a history of muscle pain or discomfort. Of the 12 patients, 5 patients received venlafaxine at doses of ≤225 mg/d, whereas the remaining 7 patients received doses exceeding 225 mg/d. The main clinical symptoms included myalgia, muscle weakness, and renal injury. All 12 patients discontinued venlafaxine and received symptomatic care.

CONCLUSIONS:

Venlafaxine, used either as a monotherapy or in combination with other drugs, may be associated with rhabdomyolysis. Creatine kinase levels may normalize or significantly decrease after discontinuation of venlafaxine and symptomatic treatment.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rabdomiólise / Cloridrato de Venlafaxina Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rabdomiólise / Cloridrato de Venlafaxina Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article