FOXL2 interaction with different binding partners regulates the dynamics of ovarian development.
Sci Adv
; 10(12): eadl0788, 2024 Mar 22.
Article
em En
| MEDLINE
| ID: mdl-38517962
ABSTRACT
The transcription factor FOXL2 is required in ovarian somatic cells for female fertility. Differential timing of Foxl2 deletion, in embryonic versus adult mouse ovary, leads to distinctive outcomes, suggesting different roles across development. Here, we comprehensively investigated FOXL2's role through a multi-omics approach to characterize gene expression dynamics and chromatin accessibility changes, coupled with genome-wide identification of FOXL2 targets and on-chromatin interacting partners in somatic cells across ovarian development. We found that FOXL2 regulates more targets postnatally, through interaction with factors regulating primordial follicle formation and steroidogenesis. Deletion of one interactor, ubiquitin-specific protease 7 (Usp7), results in impairment of somatic cell differentiation, germ cell nest breakdown, and ovarian development, leading to sterility. Our datasets constitute a comprehensive resource for exploration of the molecular mechanisms of ovarian development and causes of female infertility.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ovário
/
Fatores de Transcrição Forkhead
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article