Baricitinib for refractory Takayasu arteritis: a prospective cohort study in a tertiary referral centre.
RMD Open
; 10(1)2024 Mar 22.
Article
em En
| MEDLINE
| ID: mdl-38519108
ABSTRACT
OBJECTIVE:
To investigate the treatment efficacy and safety of baricitinib in patients with refractory Takayasu arteritis (TAK).METHODS:
We performed a prospective cohort study in which baricitinib 4 mg daily was prescribed to patients with refractory TAK, combined with oral glucocorticoids (GCs).RESULTS:
10 patients with refractory TAK were enrolled with a median age of 28 (IQR=22-37) years, median disease duration of 50 (IQR=24-65) months. The median dose of GCs was 10 (IQR=8.1-22.5) mg prednisone or equivalence dosage at baseline. At 6 months of baricitinib treatment, 6/10 (60%) patients had an overall treatment response. During an average follow-up of 15.3 (range 4-31) months, 4/10 (40%) patients maintained overall treatment response. 8/10 (80%) patients tapered or maintained the same dose of GCs with no change of the combined classical synthetic disease-modifying antirheumatic drugs. Two patients discontinued GCs at 18 and 24 months and were in continuous remission till the end of the study. One patient withdrew baricitinib due to liver dysfunction.CONCLUSION:
Baricitinib 4 mg daily is effective for refractory TAK and is well tolerated.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Purinas
/
Pirazóis
/
Sulfonamidas
/
Azetidinas
/
Arterite de Takayasu
Limite:
Child, preschool
/
Humans
/
Infant
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article