Molecular docking of quercetin: a promising approach for the development of new anti-inflammatory and analgesic drugs.
Nat Prod Res
; : 1-10, 2024 Mar 23.
Article
em En
| MEDLINE
| ID: mdl-38520257
ABSTRACT
The aim of this study is to investigate the antinociceptive, anti-inflammatory and antipyretic effects of quercetin. Additionally, molecular docking studies were conducted to evaluate potential interactions between quercetin and various molecular targets. Animal models were used to conduct a comprehensive pharmacological investigation of quercetin. Evaluation of analgesic activity revealed a reduction in the number of abdominal cramps during the twisting test and inhibition of pain during the second phase of the formaldehyde test. Additionally, evaluation of its anti-inflammatory activity showed a reduction in ear oedema. However, it is important to note that quercetin administration has not been shown to significantly reduce yeast-induced hyperthermia. The docking study revealed the high inhibitory potential of quercetin against the COX-2 receptor.
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MEDLINE
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Ano de publicação:
2024
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Article