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Modeling hypoxia-induced radiation resistance and the impact of radiation sources.
Possenti, Luca; Vitullo, Piermario; Cicchetti, Alessandro; Zunino, Paolo; Rancati, Tiziana.
Afiliação
  • Possenti L; Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy. Electronic address: luca.possenti@istitutotumori.mi.it.
  • Vitullo P; MOX, Department of Mathematics, Politecnico di Milano, P.zza Da Vinci 32, Milan, 20133, Italy.
  • Cicchetti A; Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy.
  • Zunino P; MOX, Department of Mathematics, Politecnico di Milano, P.zza Da Vinci 32, Milan, 20133, Italy.
  • Rancati T; Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, 20133, Italy.
Comput Biol Med ; 173: 108334, 2024 May.
Article em En | MEDLINE | ID: mdl-38520919
ABSTRACT
Hypoxia contributes significantly to resistance in radiotherapy. Our research rigorously examines the influence of microvascular morphology on radiotherapy outcome, specifically focusing on how microvasculature shapes hypoxia within the microenvironment and affects resistance to a standard treatment regimen (30×2GyRBE). Our computational modeling extends to the effects of different radiation sources. For photons and protons, our analysis establishes a clear correlation between hypoxic volume distribution and treatment effectiveness, with vascular density and regularity playing a crucial role in treatment success. On the contrary, carbon ions exhibit distinct effectiveness, even in areas of intense hypoxia and poor vascularization. This finding points to the potential of carbon-based hadron therapy in overcoming hypoxia-induced resistance to RT. Considering that the spatial scale analyzed in this study is closely aligned with that of imaging data voxels, we also address the implications of these findings in a clinical context envisioning the possibility of detecting subvoxel hypoxia.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fótons / Hipóxia Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fótons / Hipóxia Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article