Antiviral treatment for Ramsay Hunt syndrome: A systematic review and meta-analysis.
Auris Nasus Larynx
; 51(3): 488-491, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38520982
ABSTRACT
OBJECTIVE:
This study aimed to reveal the efficacy and safety of antivirals in patients with Ramsay Hunt syndrome.METHODS:
A literature search was conducted in PubMed, Ichushi-Web, and Cochrane Central Register of Controlled Trials. Published randomized controlled trials and observational studies, which compared antivirals versus placebo/no treatment for Ramsay Hunt syndrome, were included in the meta-analysis. The primary outcome was non-recovery at the end of the study follow-up. Data was analyzed using Review Manager Software, and pooled odds ratio (OR) with 95 % CI were calculated.RESULTS:
Two randomized controlled trials and 7 cohort studies met the eligible criteria, and 474 individuals were included in the meta-analysis. The OR of antivirals for non-recovery was 0.68 (95 % CI 0.37-1.27, p = 0.22). In subgroup analysis, the OR were 0.48 (95 % CI 0.15-1.61, p = 0.24) in patients with antivirals monotherapy and 0.73 (95 % CI 0.34-1.57, p = 0.42) in patients treated with combination therapy of antivirals and systematic corticosteroid.CONCLUSION:
This systematic review first shows the effectiveness of antivirals. Further study is needed to confirm the efficacy of antivirals.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Herpes Zoster da Orelha Externa
/
Quimioterapia Combinada
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article