FGF17 protects cerebral ischemia reperfusion-induced blood-brain barrier disruption via FGF receptor 3-mediated PI3K/AKT signaling pathway.

Huang, Wen-Ting; Chen, Xiong-Jian; Lin, Yu-Kai; Shi, Jun-Feng; Li, Hong; Wu, Hao-Di; Jiang, Ruo-Lin; Chen, Shuai; Wang, Xue; Tan, Xian-Xi; Chen, Ke-Yang; Wang, Peng

Huang, Wen-Ting; Chen, Xiong-Jian; Lin, Yu-Kai; Shi, Jun-Feng; Li, Hong; Wu, Hao-Di; Jiang, Ruo-Lin; Chen, Shuai; Wang, Xue; Tan, Xian-Xi; Chen, Ke-Yang; Wang, Peng.

Afiliação

Huang WT; Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, China.
Chen XJ; Department of Pharmacy, Wenzhou Central Hospital, Wenzhou, 325099, China.
Lin YK; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Shi JF; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Li H; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Wu HD; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Jiang RL; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Chen S; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Wang X; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Tan XX; Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, China. Electronic address: drtxxwz@163.com.
Chen KY; Department of Neurology, The Second Affiliated Hospital and Yuying Children' Hospital of Wenzhou Medical University, Wenzhou, 325027, China. Electronic address: chenky128@126.com.
Wang P; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China. Electronic address: wp1989_wmu@wmu.edu.cn.

Eur J Pharmacol ; 971: 176521, 2024 May 15.

Article em En | MEDLINE | ID: mdl-38522639

Assuntos

Isquemia Encefálica; AVC Isquêmico; Traumatismo por Reperfusão; Ratos; Humanos; Camundongos; Animais; Barreira Hematoencefálica/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Células Endoteliais; Fosfatidilinositol 3-Quinases/metabolismo; Ratos Sprague-Dawley; Transdução de Sinais; Isquemia Encefálica/tratamento farmacológico; Isquemia Encefálica/metabolismo; Reperfusão; Oxigênio/metabolismo; Traumatismo por Reperfusão/tratamento farmacológico; Traumatismo por Reperfusão/prevenção & controle; Traumatismo por Reperfusão/metabolismo; Infarto da Artéria Cerebral Média/complicações; Infarto da Artéria Cerebral Média/tratamento farmacológico; Infarto da Artéria Cerebral Média/metabolismo; AVC Isquêmico/metabolismo; Receptores de Fatores de Crescimento de Fibroblastos/metabolismo; Receptores de Fatores de Crescimento de Fibroblastos/uso terapêutico; Fatores de Crescimento de Fibroblastos/metabolismo

Palavras-chave

Apoptosis; Blood-brain barrier; Cerebral ischemia; FGF17; PI3K/Akt signaling pathway

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Isquemia Encefálica / AVC Isquêmico Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google