Your browser doesn't support javascript.
loading
Separating distant recurrences from second primaries in head and neck squamous cell carcinomas - A DAHANCA group analysis on paired tumor samples.
Kjems, Julie; Lilja-Fischer, Jacob Kinggaard; Friborg, Jeppe; Tramm, Trine; Overgaard, Jens.
Afiliação
  • Kjems J; Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.
  • Lilja-Fischer JK; Department of Oncology, Copenhagen University Hospital, Copenhagen, Denmark.
  • Friborg J; Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.
  • Tramm T; Department of Oncology, Copenhagen University Hospital, Copenhagen, Denmark.
  • Overgaard J; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark.
Head Neck ; 2024 Mar 25.
Article em En | MEDLINE | ID: mdl-38528796
ABSTRACT

BACKGROUND:

In head and neck squamous cell carcinomas (HNSCC), there is no clinically available method to separate distant metastases (DMs) from SCC secondary primary tumors. The study aimed to assess the genetic relationship in paired tumor samples.

METHODS:

Patients with pairs of solid biopsies from the primary HNSCC and suspected DMs were identified (2007-2017). Targeted next-generation sequencing of 22 genes was applied, including TP53, supplemented with human papillomavirus (HPV) genotyping.

RESULTS:

Of 55 pairs obtained, 33 were successfully analyzed. Distant biopsies included lung, liver, and bone. A genetic match was found in 23/33 (70%) patients, primarily with identical TP53 mutations or HPV genotypes. In 10/33 patients (30%), the genetic relationship was absent, all with lung involvement. In patients with no lung involvement, 8/8 had a match.

CONCLUSIONS:

One-third of patients with DMs in HNSCC lack a genetic relationship with the primary tumors. The risk of misclassification is most prominent for patients with lung involvement.
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article