High-spatial-resolution transcranial focused ultrasound neuromodulation using frequency-modulated pattern interference radiation force.
Ultrasonics
; 140: 107298, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38531115
ABSTRACT
Stimulating the brain in a precise location is crucial in ultrasound neuromodulation. However, improving the resolution proves a challenge owing to the characteristics of transcranial focused ultrasound. In this paper, we present a new neuromodulation system that overcomes the existing limitations based on an acoustic radiation force with a frequency-modulated waveform and standing waves. By using the frequency-modulated pattern interference radiation force (FM-PIRF), the axial spatial resolution can be reduced to a single wavelength level and the target location can be controlled in axial direction electronically. A linear frequency-modulated chirp waveform used in the experiment was designed based on the simulation results. The displacement of the polydimethylsiloxane (PDMS) cantilever was measured at intervals of 0.1 mm to visualize the distribution of radiation force. These results and methods experimentally show that FM-PIRF has improved spatial resolution and capability of electrical movement.
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MEDLINE
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Desenho de Equipamento
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article