Biocatalytic Synthesis of Coumarin S-Glycosides: Towards Non-Cytotoxic Probes for Biomedical Imaging and Sensing.
Molecules
; 29(6)2024 Mar 16.
Article
em En
| MEDLINE
| ID: mdl-38542958
ABSTRACT
This study unveils an innovative method for synthesizing coumarin S-glycosides, employing original biocatalysts able to graft diverse carbohydrate structures onto 7-mercapto-4-methyl-coumarin in one-pot reactions. The fluorescence properties of the generated thio-derivatives were assessed, providing valuable insights into their potential applications in biological imaging or sensing. In addition, the synthesized compounds exhibited no cytotoxicity across various human cell lines. This research presents a promising avenue for the development of coumarin S-glycosides, paving the way for their application in diverse biomedical research areas.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cumarínicos
/
Glicosídeos
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article