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Longitudinal observational cohort study: Speech for Intelligent cognition change tracking and DEtection of Alzheimer's Disease (SIDE-AD).
Saunders, Stina; Haider, Fasih; Ritchie, Craig W; Muniz Terrera, Graciela; Luz, Saturnino.
Afiliação
  • Saunders S; University of Edinburgh, Edinburgh, UK Stina.Saunders@ed.ac.uk.
  • Haider F; Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Ritchie CW; Department of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
  • Muniz Terrera G; Scottish Brain Sciences, Edinburgh, UK.
  • Luz S; Centre for Dementia Prevention, University of Edinburgh, Edinburgh, UK.
BMJ Open ; 14(3): e082388, 2024 Mar 28.
Article em En | MEDLINE | ID: mdl-38548356
ABSTRACT

INTRODUCTION:

There is emerging evidence that speech may be a potential indicator and manifestation of early Alzheimer's disease (AD) pathology. Therefore, the University of Edinburgh and Sony Research have partnered to create the Speech for Intelligent cognition change tracking and DEtection of Alzheimer's Disease (SIDE-AD) study, which aims to develop digital speech-based biomarkers for use in neurodegenerative disease. METHODS AND

ANALYSIS:

SIDE-AD is an observational longitudinal study, collecting samples of spontaneous speech. Participants are recruited from existing cohort studies as well as from the National Health Service (NHS)memory clinics in Scotland. Using an online platform, participants record a voice sample talking about their brain health and rate their mood, anxiety and apathy. The speech biomarkers will be analysed longitudinally, and we will use machine learning and natural language processing technology to automate the assessment of the respondents' speech patterns. ETHICS AND DISSEMINATION The SIDE-AD study has been approved by the NHS Research Ethics Committee (REC reference 23/WM/0153, protocol number AC23046, IRAS Project ID 323311) and received NHS management approvals from Lothian, Fife and Forth Valley NHS boards. Our main ethical considerations pertain to the remote administration of the study, such as taking remote consent. To address this, we implemented a consent process, whereby the first step of the consent is done entirely remotely but a member of the research team contacts the participant over the phone to consent participants to the optional, most sensitive, elements of the study. Results will be presented at conferences, published in peer-reviewed journals and communicated to study participants.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Doença de Alzheimer Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article