Hyparillums A and B: polycyclic polyprenylated acylphloroglucinols from Hypericum patulum.
Chin J Nat Med
; 22(3): 273-279, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-38553194
ABSTRACT
Hyparillums A (1) and B (2), two previously unidentified polycyclic polyprenylated acylphloroglucinols (PPAPs) with intricate architectures, were isolated from Hypericum patulum Thunb. Hyparillum A was the first PPAP with eight-carbon rings based on an unprecedented 6/6/5/6/6/5/6/4 octocyclic system featuring a rare heptacyclo[10.8.1.11,10.03,8.08,21.012,19.014,17]docosane core. In contrast, hyparillum B featured a novel heptacyclic architecture (6/6/5/6/6/5/5) based on a hexacyclo[9.6.1.11,9.03,7.07,18.011,16]nonadecane motif. Furthermore, hyparillums A and B demonstrated promising inhibitory effects on the proliferation of murine splenocytes stimulated by anti-CD3/anti-CD28 monoclonal antibodies and lipopolysaccharide, exhibiting half-maximal inhibitory concentration (IC50) values ranging from 6.13 ± 0.86 to 12.69 ± 1.31 µmol·L-1.
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Base de dados:
MEDLINE
Assunto principal:
Hypericum
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article