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Real-life management of psoriasis with biological agents during pregnancy.
Tran, C; Mahé, E; Beylot-Barry, M; Jullien, D; Richard, M-A; Fougerousse, A-C; Bouznad, A; Bulai Livideanu, C; Brun, A; Amelot, F; Maccari, F; Aubin, F; Benhadou, F; Paul, C.
Afiliação
  • Tran C; Department of Dermatology, Toulouse University Hospital, 31400 Toulouse, France.
  • Mahé E; Department of Dermatology, Victor Dupouy Hospital, 95107 Argenteuil, France; Groupe d'Etudes Multicentriques (GEM) Resopso, France; GRPso (Groupe de Recherche sur le Psoriasis de la Société Française de Dermatologie), France.
  • Beylot-Barry M; Department of Dermatology, Bordeaux University Hospital, 33000 Bordeaux, France; GRPso (Groupe de Recherche sur le Psoriasis de la Société Française de Dermatologie), France.
  • Jullien D; Department of Dermatology, Lyon University Hospital, 69003 Lyon, France; GRPso (Groupe de Recherche sur le Psoriasis de la Société Française de Dermatologie), France.
  • Richard MA; Department of Dermatology, Marseille University Hospital, 13005 Marseille, France; GRPso (Groupe de Recherche sur le Psoriasis de la Société Française de Dermatologie), France.
  • Fougerousse AC; Department of Dermatology, Hôpital d'Instruction des Armées Bégin, France; Groupe d'Etudes Multicentriques (GEM) Resopso, France.
  • Bouznad A; Department of Dermatology, Toulouse University Hospital, 31400 Toulouse, France.
  • Bulai Livideanu C; Department of Dermatology, Toulouse University Hospital, 31400 Toulouse, France; Groupe d'Etudes Multicentriques (GEM) Resopso, France.
  • Brun A; Department of Dermatology, Toulouse University Hospital, 31400 Toulouse, France.
  • Amelot F; Department of Dermatology, Carcassonne Hospital, 11000 Carcassonne, France.
  • Maccari F; Department of Dermatology, Hôpital d'Instruction des Armées Bégin, France; Groupe d'Etudes Multicentriques (GEM) Resopso, France.
  • Aubin F; Department of Dermatology, Besançon University Hospital, 25000 Besançon, France; GRPso (Groupe de Recherche sur le Psoriasis de la Société Française de Dermatologie), France.
  • Benhadou F; Department of Dermatology, Erasme Hôpital universitaire, Université Libre de Bruxelles, 1070 Brussels, Belgium; Groupe d'Etudes Multicentriques (GEM) Resopso, France.
  • Paul C; Department of Dermatology, Toulouse University Hospital, 31400 Toulouse, France; GRPso (Groupe de Recherche sur le Psoriasis de la Société Française de Dermatologie), France. Electronic address: paul.c@chu-toulouse.fr.
Ann Dermatol Venereol ; 151(2): 103254, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38554588
ABSTRACT

BACKGROUND:

French guidelines recommend stopping biologic treatment of psoriasis between 3 and 24 weeks before conception in accordance with the relevant Summary of Product Characteristics (SmPC). The aim of this study was to evaluate the real-life practice of dermatologists in the management of pregnant women with psoriasis previously treated with biologic agents. We wished to assess the level of practitioner adherence to the relevant SmPCs. MATERIAL AND

METHODS:

We conducted a study in collaboration with GRPso and Resopso. A computerized questionnaire was completed by the practitioners. We performed descriptive statistics and studied the profile of the practitioners, their level of confidence with continuation of biological agents during pregnancy, and their reported practices on the use of biological agents in pregnancy. Statistical analyses were performed using XLSTAT. A p-value of less than 0.05 was considered significant.

RESULTS:

A total of 63 dermatologists (women 71%; mean age 43.8 years) participated in this study, the majority of whom were hospital-based (87%). Recommendations were followed by 36.5% of practitioners, while 44% reported discontinuing biologic agents on diagnosis of pregnancy, and 20.5% reported using these agents during pregnancy. Among dermatologists with more than ten years of experience, 19% reported following the SmPC. Among dermatologists with a patient base >200 (patients treated with biologic agents for psoriasis), 19% reported following the SmPC compared to 54% of practitioners with less than 50 patients. The mean age of dermatologists following the SmPC was 41 years vs. 47 years for those not following the SmPC.

DISCUSSION:

The majority of practitioners do not follow recommendations on discontinuation of biologic agents before the planning of pregnancy by patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complicações na Gravidez / Psoríase Limite: Adult / Female / Humans / Middle aged / Pregnancy País como assunto: Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Complicações na Gravidez / Psoríase Limite: Adult / Female / Humans / Middle aged / Pregnancy País como assunto: Europa Idioma: En Ano de publicação: 2024 Tipo de documento: Article