Safety and efficacy of nivolumab therapy in patients with metastatic renal cell carcinoma and impaired kidney function.
Actas Urol Esp (Engl Ed)
; 48(4): 273-280, 2024 May.
Article
em En, Es
| MEDLINE
| ID: mdl-38570033
ABSTRACT
INTRODUCTION:
Patients with renal insufficiency, usually defined as those with creatinine clearanceâ¯<â¯40â¯mL/min, were excluded from pivotal clinical trials, especially in studies involving nivolumab therapy in patients with renal cell carcinoma (RCC). The aim of the study is to evaluate the efficacy and safety of nivolumab in patients with metastatic RCC (mRCC) stratified according to creatinine clearance. MATERIAL ANDMETHODS:
Data from mRCC patients treated with nivolumab were retrospectively analyzed. Patients were classified into two categories according to their estimated glomerular filtration rate (eGFR); the first category (C1) included patients with eGFRâ¯<â¯40â¯mL/min/1.73â¯m2 and the second category (C2) included those with eGFRâ¯≥â¯40â¯mL/min/1.73â¯m2.RESULTS:
Of the 95 patients enrolled, 1. group included 26 patients (27.4%) and 2. group included 69 patients (72.6%). None of the pts in category 1 were on hemodialysis. Overall incidence of adverse events was not statistically different between the two groups (Pâ¯=â¯.469). The overall response rate ORR was 50% in the first group and 42.0% in the second group (Pâ¯=â¯.486). Median overall survival (OS) was longer with 23.3 months in the 2. group versus 11 months in the 1. group (Pâ¯=â¯.415).CONCLUSION:
Renal insufficiency is a common problem in patients with advanced renal cancer since they often undergo nephrectomy and their renal function may also worsen while receiving tyrosine kinase inhibitor therapy. We found that there is no significant difference in the safety and efficacy of nivolumab treatment between two groups. Nivolumab appears to be a safe and effective agent in patients with renal impairment.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Renais
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Antineoplásicos Imunológicos
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Nivolumabe
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Neoplasias Renais
Limite:
Humans
Idioma:
En
/
Es
Ano de publicação:
2024
Tipo de documento:
Article