Endothelial function in patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors is not related to cardiovascular risk assessed by the Systematic Coronary Risk Estimation 2 algorithm.
Pol Arch Intern Med
; 134(6)2024 06 27.
Article
em En
| MEDLINE
| ID: mdl-38572907
ABSTRACT
INTRODUCTION:
Tyrosine kinase inhibitors (TKIs) revolutionized treatment of chronic myeloid leukemia (CML), but are endowed with negative effects on endothelial function.OBJECTIVES:
We aimed to characterize endothelial function in patients with CML treated with various TKIs. PATIENTS ANDMETHODS:
A total of 48 patients diagnosed with chronicphase CML treated with TKIs, such as imatinib, bosutinib, nilotinib, ponatinib, and asciminib were included. Endothelial function was assessed in the brachial artery and microcirculation based on flowmediated dilation (FMD), reactive hyperemia peripheral arterial tonometry (RHPAT) and flowmediated skin fluorescence (FMSF).RESULTS:
Reactive hyperemia index, FMD, reactive hyperemia response (RHR), normoxia oscillatory index, and hyperemic response index did not differentiate between the group of patients with low / moderate risk in the Systematic Coronary Risk Estimation 2 (SCORE2), SCORE2Older Persons (SCORE2OP), and those with high / very high risk scores. Among the patients with low / intermediate risk based on the SCORE2 algorithm, some had lower (below the first quartile) values of the endothelial parameters, reflecting impaired endothelial function, as compared with the high / very high risk patient population. Lower values of the endothelial function parameters were associated with overall longterm treatment with TKIs or ponatinib. Importantly, endothelial function assessed by FMSF (RHR) negatively correlated with total duration of TKI treatment, also after adjustment for age.CONCLUSIONS:
Endothelial function in CML patients treated with TKIs was not related to cardiovascular risk based on SCORE2/SCORE2OP algorithms but correlated with CMLspecific factors, including duration of TKI treatment. FMSFbased assessment of skin microcirculation was a sensitive method for detecting the vascular effects of TKIs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mielogênica Crônica BCR-ABL Positiva
/
Inibidores de Proteínas Quinases
Limite:
Adult
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Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article