Impact of sphingolipid synthesis inhibition on the drug susceptibility patterns of Trichophyton species.
Diagn Microbiol Infect Dis
; 109(2): 116283, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38574446
ABSTRACT
The well known dermatophyte infections caused by Trichophyton species are an ambiguous problem to treat using the present arsenal of antifungals. This study expounds on the effect of inhibition of sphingolipid pathway on Trichophyton growth. Findings from the drug susceptibility assays suggest sphingolipid inhibition severely restricts the growth of T. interdigitale and T. tonsurans. The observed synergistic effects of combinations of sphingolipid inhibitor and conventional drugs provide a promising treatment strategy against Trichophyton infection.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Esfingolipídeos
/
Trichophyton
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Testes de Sensibilidade Microbiana
/
Antifúngicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article