The role of TIM-3 in sepsis: a promising target for immunotherapy?
Front Immunol
; 15: 1328667, 2024.
Article
em En
| MEDLINE
| ID: mdl-38576606
ABSTRACT
Sepsis remains a significant cause of mortality and morbidity worldwide, with limited effective treatment options. The T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) has emerged as a potential therapeutic target in various immune-related disorders. This narrative review aims to explore the role of TIM-3 in sepsis and evaluate its potential as a promising target for immunotherapy. We discuss the dynamic expression patterns of TIM-3 during sepsis and its involvement in regulating immune responses. Furthermore, we examine the preclinical studies investigating the regulation of TIM-3 signaling pathways in septic models, highlighting the potential therapeutic benefits and challenges associated with targeting TIM-3. Overall, this review emphasizes the importance of TIM-3 in sepsis pathogenesis and underscores the promising prospects of TIM-3-based immunotherapy as a potential strategy to combat this life-threatening condition.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sepse
/
Receptor Celular 2 do Vírus da Hepatite A
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article